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Lysergic acid 3-pentyl amide
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Lysergic acid 3-pentyl amide : ウィキペディア英語版
Lysergic acid 3-pentyl amide

Lysergic acid 3-pentyl amide (3-Pentyllysergamide, LSP) is an analogue of LSD originally researched by David E. Nichols and colleagues at Purdue University. It has similar binding affinity to LSD itself as both a 5-HT1A and 5-HT2A agonist, and produces similar behavioral and physiological responses in animals with only slightly lower potency than LSD. Other isomers of this compound have also been explored, with the 1-pentylamide being around 75% the potency of LSD,〔David E. Nichols. LSD and Its Lysergamide Cousins. ''The Heffter Review of Psychedelic Research''. 2001;2:80-87.〕 while the (R)-2-pentylamide shows similar 5-HT2A binding affinity to LSD ''in vitro'' but has only around half the potency of LSD in producing drug-appropriate responding in mice, and the (S)-2-pentylamide is inactive.〔Monte AP, Marona-Lewicka D, Kanthasamy A, Sanders-Bush E, Nichols DE. Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. ''Journal of Medicinal Chemistry''. 1995 Mar 17;38(6):958-66. PMID 7699712〕
==See also==

* Lysergic acid 2-butyl amide
* Methylisopropyllysergamide

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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